Aptamer 学术简报 — 2026-09-28

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 157 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.2] pH-dependent allosteric remodeling of a bacterial riboswitch couples alkaline activation to metal sensing.

The widespread yybP-ykoY riboswitches control bacterial manganese (Mn) homeostasis by activating exporter expression in response to intracellular Mn2+ levels. The Escherichia coli alx riboswitch distinctively couples Mn2+ sensing to cytoplasmic alkalinity, but the mechanism is unknown. We show that pH tunes the alx aptamer's conformational sampl...

#2 [15.2] Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer.

Serotonin is a key neurotransmitter, and aptamer-based tools using the 44-nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high-resolution NMR structures of Apt38, a 6-nt truncated variant in the third loop of Apt44...

#3 [15.0] Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma.

Therapeutic strategies for glioblastoma have progressed considerably over recent decades. Despite the development of new biomedical technologies and advances in our understanding of physiology and disease progression, effective drug delivery to brain cancer remains a significant challenge. The challenge is delivering therapeutics to the correct ...

#4 [15.0] Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.

In vivo continuous molecular monitoring represents a long-standing, transformative objective in medicine, with the potential to fundamentally reshape disease diagnostics, therapeutic decision-making, and long-term patient management by providing dynamic biochemical information that is currently inaccessible. Electrochemical aptamer-based biosens...

#5 [14.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities

ABSTRACT Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real‐time collection of photoelectrochemical signals in brain slices. Meanwhile, a se...

#6 [14.9] A Self-Propelled DNA-Based Nanorobot for Hypoxic Tumor Therapy.

Solid tumors pose major therapeutic hurdles due to pathophysiological barriers such as hypoxia and dense stroma, which severely restrict drug penetration. Conventional nanomedicines lack the autonomous capability to navigate these evolving obstacles. Here, we engineer a DNA‑based nanorobot constructed on an optimized tetrahedral framework nuclei...

#7 [14.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities.

Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real-time collection of photoelectrochemical signals in brain slices. Meanwhile, a serotonin (...

#8 [13.8] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#9 [13.8] DNA Nanoassembly Modified Polydopamine@MnO(2) Nanoparticles: Enhancement of miRNA-21 Downregulation for Reversal of Breast Cancer Drug-Resistance.

Downregulating oncogenic microRNAs (miRNAs) is an attractive strategy for reversing drug resistance in cancer therapy. Compared to antisense, DNAzyme (Dz) possesses advantages such as recyclability and stability. However, it still suffers from insufficient stability and inadequate endogenous cofactors. Herein, by using miRNA-21 (miR-21) as targe...

#10 [13.5] ShapeME: A Tool and Web Front-end for De Novo Discovery of Structural Motifs Underpinning Protein-DNA Interactions.

Determining where proteins bind a genome is paramount to understanding gene regulation. In addition to DNA sequence motifs, structural motifs (e.g., a narrow minor groove width) determine binding for some proteins (Rohs et al., 2009) [1]. Algorithms using structural features of DNA to predict protein binding exist (Mathelier et al., 2016; Samee ...

Methodology