Aptamer 学术简报 — 2026-09-22

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 130 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.2] ShapeME: A Tool and Web Front-end for De Novo Discovery of Structural Motifs Underpinning Protein-DNA Interactions.

Determining where proteins bind a genome is paramount to understanding gene regulation. In addition to DNA sequence motifs, structural motifs (e.g., a narrow minor groove width) determine binding for some proteins (Rohs et al., 2009) [1]. Algorithms using structural features of DNA to predict protein binding exist (Mathelier et al., 2016; Samee ...

#2 [16.1] Selection and validation of novel DNA aptamer panel co-specific to Plasmodium falciparum and Plasmodium ovale lactate dehydrogenase.

Malaria remains a major global health concern. The development of point-of-care diagnostic aptasensors could improve malaria detection, patient management, and eradication efforts. We selected and validated single-stranded DNA aptamers against Plasmodium falciparum lactate dehydrogenase (Pf-LDH), using systematic evolution of ligands by exponent...

#3 [14.8] Shared-Output Aptamer-Gated DNA Nanodevices Program NbaSPARDA Trans-Cleavage for Metabolite and Drug Sensing.

Routing chemically distinct small-molecule aptamers into a common nuclease trans-cleavage pathway is constrained by the target-specific output handles of conventional structure-switching aptamers (SSAs). Shared-output aptamer-gated DNA nanodevices are designed so that recognition cores control release of the same short trigger DNA (tDNA). The re...

#4 [14.6] Modular Lysosome-Targeting Platform Based on a Multivalent DNA Framework for Programmable Protein Degradation.

Targeted degradation of extracellular and membrane-bound proteins holds immense therapeutic potential but remains technically challenging. Lysosome-targeting chimeras (LYTACs) have emerged to bridge this gap, yet platforms built on monomeric aptamers suffer from inadequate stability, inefficient cellular uptake, and a lack of modularity. Here, w...

#5 [14.2] An engineered nanopore identifies saccharides, amino acids, peptides and ribonucleotides

#6 [14.2] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#7 [14.0] Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silencing B-Cell Lymphoma 2.

Acute Myeloid Leukemia (AML) is a prevalent and aggressive hematologic cancer driven by leukemic stem cells and immune evasion. Among its subtypes, Mixed Lineage Leukemia-AF9 (MLL-AF9)- rearranged AML is exceptionally lethal, with B-cell lymphoma 2 (Bcl2), a key anti-apoptotic protein, supporting leukemic survival and immune dysfunction. Targeti...

#8 [13.6] Electrospun nanofiber-based solid-phase extraction coupled with aptamer-mediated FRET assay for detection of aflatoxin M(1) in milk.

BACKGROUND: Aflatoxin M1 (AFM1), a highly toxic hydroxylated metabolite of aflatoxin B1, is a major contaminant of concern in milk and dairy products, posing significant risks to food safety and public health. Since AFM1 contamination is closely associated with feed quality, storage conditions, climatic factors, and farm management, reliable AFM...

#9 [13.5] Universal contamination-free nucleic acid biosensing enabled by guide-independent Argonaute amplicon elimination

Amplicon contamination remains a major challenge in nucleic acid biosensing, frequently compromising diagnostic accuracy in both clinical testing and field-deployable sensing systems. Although strategies such as uracil-DNA glycosylase (UDG) treatment and CRISPR-based approaches have been developed to mitigate this problem, their broader implemen...

#10 [13.3] Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

ABSTRACT Electrochemical point‐of‐care testing for complex clinical samples is frequently hampered by matrix interference, signal instability, and laborious electrode modification procedures. Herein, we report a magnetic portable electrochemical immunosensor utilizing a conductive, anti‐fouling hydrogel coating composed of sodium alginate, polye...

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