Aptamer 学术简报 — 2026-09-01

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 199 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.2] A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation.

Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF-α-mediated immune-epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD)...

#2 [15.0] Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis.

Rheumatoid arthritis (RA) progression is driven by the pathogenic transformation of stromal fibroblast-like synoviocytes (FLSs). Using artificial intelligence-guided analysis of a synovial single-cell transcriptomic dataset, we identify O-GlcNAc transferase (OGT) as a key regulator enriched in RA-FLSs. Gain- and loss-of-function studies demonstr...

#3 [14.8] Aptamer-mediated portable SERS sensor based on bimetallic magnetic nanotubes for internal standard-calibrated detection of multi-target disease markers.

Accurate early screening for hepatocellular carcinoma (HCC) requires multi-target detection methods with high sensitivity and strong anti-interference capability. In this study, we developed an aptamer-mediated SERS sensing method based on bimetallic magnetic nanotubes for the simultaneous detection of HCC markers alpha-fetoprotein (AFP) and Gol...

#4 [14.8] Double-target responsive FRET sensor based on DNA tetrahedron for robust detection of liver fibrosis-related mRNAs in activated hepatic stellate cells.

Early diagnosis and graded evaluation of liver fibrosis remained challenging due to the limited sensitivity and accuracy of current noninvasive diagnostic tools. The imaging strategy of intracellular disease-related biomarker based on DNA nanoparticles had been used for accurate diagnosis and prognosis studies. However, their sensitivity and acc...

#5 [14.8] A novel triple-mode sensor utilizing trimetallic derived fluorescent carbon dots nanozyme for tetracycline determination.

Tetracycline (TC) is notoriously resistant to degradation in natural environments, which contributes to its prolonged persistence and widespread contamination. Improper or excessive use of TC can lead to multifaceted hazards. In this study, we developed a trimetallic-doped carbon dots (Fe,Cu,Ce-CDs)-based composite that exhibits distinct fluores...

#6 [14.8] Breaking boundaries for PFAS surveillance in water reservoirs: CRISPR-electrochemical synergies from MXene to microfluidics- A review.

The hydro-spherical contamination of water resources by per- and polyfluoroalkyl substances (PFAS) demands analytical technologies that transcend the limitations of current methods, which struggle to simultaneously achieve ultra-sensitivity, specificity, portability, and low cost. Therefore, this review advances next-generation PFAS surveillance...

#7 [14.8] Self-powered photoelectrochemical aptasensor based on CHA-triggered G-quadruplex/hemin cascade for homogeneous detection of ochratoxin A in a separated-coupling electrolysis system.

To address the challenge of electroactive interferences derived from complex food matrices during homogeneous photoelectrochemical (PEC) biosensing, a "separated-coupling" electrolysis platform was rationally engineered for the ultrasensitive detection of ochratoxin A (OTA). Based on the analysis of the conduction band of the α-Fe2O3 photoanode ...

#8 [14.2] Evolving an Aptameric Nose for Synthetic Cannabinoids Through Modular Reprogramming of Specificity.

Discerning subtle structural differences among highly similar small molecules remains a major challenge for synthetic receptors. Natural olfactory systems solve this problem using cross-reactive receptor families that combine a conserved docking core with hypervariable specificity domains. Despite the modular nature of nucleic acid aptamers, the...

#9 [13.8] Rational design of Cr(VI) aptamer guided by revealed cation-mediated binding mechanism and construction of a label-free fluorescent aptasensor.

Aptasensors are widely recognized as practical and rapid detection tools for heavy metal pollution due to their high specificity and sensitivity. However, screening aptamers for small molecules (including ions) is significantly challenging. To date, only two Cr(VI) aptamers have been reported, which cannot meet the demand of aptasensor developme...

#10 [13.8] From rational engineering of a broad-spectrum aptamer to multi-residue screening: A fluorescent aptasensor for multiplexed sulfonamides.

The increasing prevalence of multiple antibiotic residues in animal-derived foods presents significant challenges for monitoring efforts. Broad-spectrum aptamers offer great promise for enabling multiplex detection of various antibiotic residues. However, aptamers directly screened for this purpose often exhibit low affinity and poor stability, ...

Methodology