Aptamer 学术简报 — 2026-08-30

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 180 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.9] A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation.

Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF-α-mediated immune-epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD)...

#2 [14.9] Evolving an Aptameric Nose for Synthetic Cannabinoids Through Modular Reprogramming of Specificity.

Discerning subtle structural differences among highly similar small molecules remains a major challenge for synthetic receptors. Natural olfactory systems solve this problem using cross-reactive receptor families that combine a conserved docking core with hypervariable specificity domains. Despite the modular nature of nucleic acid aptamers, the...

#3 [14.1] Cell‐Like Portable Biologics‐Free Sensors for Stress Diagnostics

ABSTRACT Mental health is a pressing and widespread global concern, necessitating accessible, reliable and cost‐effective tools for its ongoing monitoring and effective management. Herein, a portable “molecule‐probe” platform is presented that integrates a specific chemical reaction within a hydrogel microreactor with n ‐type semiconductor dopin...

#4 [13.8] Responsive reconstruction-driven autocatalysis DNA circuit for efficient and amplifiable electrochemical biosensing.

To overcome low strand utilization and slow kinetics in traditional entropy-driven DNA circuits, herein we propose a novel responsive reconstruction-driven Autocatalysis DNA Circuit (rrADC) for constructing highly sensitive electrochemical biosensor. Using 17β-estradiol as a targeted ligand, the specific ligand-aptamer binding triggers the relea...

#5 [13.8] An aptamer-guided flow-cytometric biosensor for simultaneous sizing and polymer identification of nanoplastics.

Nanoplastics are an emerging class of environmental contaminants whose analysis is limited by the difficulty of resolving both particle size and polymer identity at the submicrometre scale in a single high-throughput measurement. Here, a dual-parameter flow-cytometric biosensor was developed that combined polymer-selective DNA aptamers with viol...

#6 [13.6] CRISPR-Cas12a cleavage-based fluorescence biosensor to detect arsenic content in rice grains from different regions of China.

Nano-based sensors play a significant role in detection of heavy metals. Arsenic contaminated rice poses a serious health hazard. Nano-based rapid detection of arsenic (As3+) in rice is essential to perform rapid detection. To resolve the above problem, we leveraged the trans-cleavage activity of CRISPR -Cas12a in combination with an "aptamer-lo...

#7 [13.5] An integrated litmus test platform for low-background detection and photothermal inactivation of Salmonella typhimurium via HCR-urease signal amplification.

Herein, we propose a novel "low-background" biosensing platform integrating magnetic separation and hybridization chain reaction (HCR) for signal amplification, enabling ratiometric colorimetric detection and visual observation of S. typhimurium. In the presence of S. typhimurium, specific aptamer recognition triggers the HCR to couple the ureas...

#8 [13.3] A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA-based gene silencing, where off-target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual-AND logic gates, which enables the development of a spatiotemporally controll...

#9 [13.1] Zwitterionic polymer-modified silicon nanowire field-effect transistor biosensor for interleukin-6 detection in saliva.

As a key inflammatory cytokine biomarker, interleukin-6 (IL-6) plays an essential role in the early diagnosis of inflammatory diseases. Nevertheless, long-term, continuous biosensing monitoring of ultralow-level IL-6 remains great challenges owing to severe nonspecific adsorption effects in complex biological media such as saliva. In this study,...

#10 [13.1] Highly sensitive galectin-3 electrochemical sensor based on a dual-recognition interface of cyclodextrin-integrated molecularly imprinted polymers (MIPs) and an aptamer.

Heart failure (HF) is a major global health burden, and elevated serum levels of galectin-3 (Gal3) are widely recognized as a reliable biomarker of disease progression. Accurate detection of Gal3 is vital for prognosis and effective management of HF. This study develops a dual-recognition sandwich sensor for Gal3, providing a sensitive and selec...

Methodology