Aptamer 学术简报 — 2026-08-29

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 194 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [16.5] Shell-thickness-modulated electrochemiluminescence of colloidal quantum dots for ultrasensitive PSA detection.

Electrochemiluminescence (ECL) biosensors hold great promise for clinical diagnostics, yet their performance is often constrained by the limited efficiency and stability of available luminophores in complex biological matrices. Colloidal quantum dots (QDs) have emerged as attractive alternatives to conventional emitters, but a systematic underst...

#3 [15.2] Evolving an Aptameric Nose for Synthetic Cannabinoids Through Modular Reprogramming of Specificity.

Discerning subtle structural differences among highly similar small molecules remains a major challenge for synthetic receptors. Natural olfactory systems solve this problem using cross-reactive receptor families that combine a conserved docking core with hypervariable specificity domains. Despite the modular nature of nucleic acid aptamers, the...

#4 [14.5] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#5 [14.5] Cell‐Like Portable Biologics‐Free Sensors for Stress Diagnostics

ABSTRACT Mental health is a pressing and widespread global concern, necessitating accessible, reliable and cost‐effective tools for its ongoing monitoring and effective management. Herein, a portable “molecule‐probe” platform is presented that integrates a specific chemical reaction within a hydrogel microreactor with n ‐type semiconductor dopin...

#6 [14.1] An aptamer-guided flow-cytometric biosensor for simultaneous sizing and polymer identification of nanoplastics.

Nanoplastics are an emerging class of environmental contaminants whose analysis is limited by the difficulty of resolving both particle size and polymer identity at the submicrometre scale in a single high-throughput measurement. Here, a dual-parameter flow-cytometric biosensor was developed that combined polymer-selective DNA aptamers with viol...

#7 [13.9] CRISPR-Cas12a cleavage-based fluorescence biosensor to detect arsenic content in rice grains from different regions of China.

Nano-based sensors play a significant role in detection of heavy metals. Arsenic contaminated rice poses a serious health hazard. Nano-based rapid detection of arsenic (As3+) in rice is essential to perform rapid detection. To resolve the above problem, we leveraged the trans-cleavage activity of CRISPR -Cas12a in combination with an "aptamer-lo...

#8 [13.7] A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA-based gene silencing, where off-target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual-AND logic gates, which enables the development of a spatiotemporally controll...

#9 [13.5] Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42.

Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath deposition (CBD) is used to...

#10 [13.5] A multifunctional electrode interface: A hybrid hexanethiol and polyethylene glycol monolayer for concurrent anti-fouling, stability, and ultrasensitive detection of ochratoxin A.

Integrating antifouling capability, operational stability, and high sensitivity into electrochemical biosensors in a simple and cost-effective manner remains a significant challenge. Herein, we present a multifunctional biointerface based on a hybrid hexanethiol and polyethylene glycol (HT-PEG) self-assembled monolayer (SAM) that concurrently ad...

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