Aptamer 学术简报 — 2026-08-25

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 206 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.2] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [18.9] Shell-thickness-modulated electrochemiluminescence of colloidal quantum dots for ultrasensitive PSA detection.

Electrochemiluminescence (ECL) biosensors hold great promise for clinical diagnostics, yet their performance is often constrained by the limited efficiency and stability of available luminophores in complex biological matrices. Colloidal quantum dots (QDs) have emerged as attractive alternatives to conventional emitters, but a systematic underst...

#3 [16.7] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#4 [15.8] Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42.

Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath deposition (CBD) is used to...

#5 [14.8] Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics

Antibiotic resistance is an increasing threat to modern medicine that calls for the discovery of new antibiotics. RNA targeting is a promising approach for antibiotic development. In particular, antisense antibiotics, dubbed ASObiotics, are an exciting class of oligomers that show promise as powerful antibiotic agents. However, limited bacterial...

#6 [14.5] Electropolymerized Aptasensor for Femtogram-Level Cytokine Detection.

Detecting cytokines at ultralow concentrations is important for the early diagnosis and monitoring of inflammatory and immune disorders, yet remains constrained by the sensitivity and stability of bioelectronic interfaces. Here, we present an electropolymerization strategy for preparing poly(amino-ʟ-tyrosine) (pALT) nanofilms as functional bioin...

#7 [14.5] Biomaterials Meet Organic Electrochemical Transistors: Materials, Interfaces, and Biosensing Frontiers

ABSTRACT Organic electrochemical transistors (OECTs) are emerging as powerful biosensing platforms, offering high transduction efficiency, low‐voltage operation, and intrinsic compatibility with aqueous and physiological environments. Central to their recent progress is the strategic integration of biomaterials, which govern interfacial charge t...

#8 [14.4] PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology

#9 [14.0] Readout of intrinsic and induced DNA shape by homeodomain transcription factor complexes.

Homeodomain transcription factors (TFs) recognize their DNA targets through both sequence-specific base contacts and readout of local DNA shape. Although intrinsic DNA structure is encoded by nucleotide sequence, it also undergoes protein-induced structural deformation upon binding. Yet, the interplay between intrinsic and protein-induced DNA sh...

#10 [13.8] Enzyme-free dual-hotspot SERS immunosensor via cascaded boronate assembly

The precise detection of CA19-9 is paramount for early cancer diagnosis and clinical monitoring. However, traditional immunoassays are often hampered by their heavy reliance on matched antibody pairs and the insufficient sensitivity of enzymatic amplification systems. To address these limitations, we report a novel, enzyme-free surface-enhanced ...

Methodology