Aptamer 学术简报 — 2026-08-16

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 173 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [31.6] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [30.1] Shell-thickness-modulated electrochemiluminescence of colloidal quantum dots for ultrasensitive PSA detection.

Electrochemiluminescence (ECL) biosensors hold great promise for clinical diagnostics, yet their performance is often constrained by the limited efficiency and stability of available luminophores in complex biological matrices. Colloidal quantum dots (QDs) have emerged as attractive alternatives to conventional emitters, but a systematic underst...

#3 [27.5] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#4 [26.6] Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42.

Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath deposition (CBD) is used to...

#5 [26.1] GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.

There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)-a scalable method that surveys intrinsic bindi...

#6 [19.1] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#7 [15.6] Author Correction: Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models.

#8 [14.9] CRISPR RNA Engineering Enables Single Nucleotide Polymorphism Discrimination in Nucleic Acid Detection

ABSTRACT Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐based diagnostic systems have emerged as powerful platforms for sensitive nucleic acid detection, yet their clinical reliability is frequently constrained by off‐target activation and insufficient discrimination of closely related sequences. This review synthesizes curre...

#9 [14.5] Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein.

CRISPR-Cas12a integrated with nanomaterials has formulated powerful biosensors for viral protein detection, addressing the urgent need for point-of-care diagnostics. However, existing platforms are hindered by either multi-step separation procedures or insufficient signal amplification, limiting their sensitivity and practicality. Here, we repor...

#10 [14.3] MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.

Organ transplantation provides a life-saving intervention for patients with end-stage lung disease; however, access to this treatment remains limited by the shortage of donor organs. Ex vivo lung perfusion (EVLP) is a platform that enables surgeons to assess extended-criteria for donor lungs prior to transplantation and has safely expanded the d...

Methodology