Aptamer 学术简报 — 2026-08-01

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 183 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [19.9] Structure-alignment-driven cross-graph modeling for functional RNA design.

RNAs are critical for biological processes, and their functions are closely tied to their three-dimensional structures. The design of RNA sequences that fold into target three-dimensional structures is a complex challenge due to the dynamic and unstable nature of RNA structures. Here we present an RNA design approach, AlignIF, that leverages mul...

#2 [15.6] Inception-level signal amplification: Cascaded DNAzyme-Cas9 nickase achieves sub-nanomolar kanamycin tracking.

BACKGROUND: Kanamycin's persistent contamination in agricultural products poses significant human health risks due to its nephrotoxicity and bioaccumulation via the food chain. Existing methods for on-site kanamycin monitoring lack sufficient sensitivity and portability, limiting their utility in field settings. The urgent need for rapid detecti...

#3 [15.6] The integration of peptoid and phosphorothioate aptamer into electrochemical biosensors for the robust antifouling detection of prostate-specific antigen in human serum.

Electrochemical biosensors for biomarker detection in complex biological media often suffer from performance degradation. Two main causes are non-specific adsorption of biomolecules and enzymolysis of immobilized biomolecules. Consequently, the development of robust antifouling electrochemical biosensors represents an imperative research task. W...

#4 [15.1] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#5 [14.9] Aptamer screening within sample matrices: Toward reliable applications.

Nucleic acid aptamers are short oligonucleotide sequences selected in vitro by Systematic Evolution of Ligands by EXponential enrichment (SELEX). As "chemical antibodies", they recognize diverse targets with high affinity and specificity through structure-dependent interactions and offer multiple attractive features. Although a few natural aptam...

#6 [14.8] Multiplexed nanophotonic sensor arrays for time-resolved biomolecular analysis.

Complex diseases arise from networks of interacting biomolecules, yet most analytical technologies measure only a limited number of interactions simultaneously. Here, we present a chirped guided-mode resonance (cGMR) photonic biosensor array for multiplexed, label-free analysis of biomolecular kinetics across hundreds of sensing sites. The platf...

#7 [14.8] Fluctuation-resilient ratiometric SERS enabled by programmable aptamer disassembly for pump-free microfluidic AKI detection.

Acute kidney injury (AKI) requires rapid and reliable biomarker quantification, yet early assessment is hindered by delayed biomarker kinetics and signal fluctuation under decentralized testing conditions. Here, we developed a pump-free microfluidic aptamer-ratiometric surface-enhanced Raman scattering (SERS) platform for simultaneous quantifica...

#8 [14.6] Structure‐Guided Redesign of Terminal Deoxynucleotidyl Transferase Enables Scalable Enzymatic DNA Synthesis for Data Storage

ABSTRACT DNA, with its exceptional information capacity and chemical stability, represents a promising material for next‐generation data storage to meet the exponential growth of global digital information demands. Enzymatic DNA synthesis provides a sustainable route to DNA production. However, the practical scalability of the underlying polymer...

#9 [14.6] Structure‐Guided Redesign of Terminal Deoxynucleotidyl Transferase Enables Scalable Enzymatic DNA Synthesis for Data Storage

ABSTRACT DNA, with its exceptional information capacity and chemical stability, represents a promising material for next‐generation data storage to meet the exponential growth of global digital information demands. Enzymatic DNA synthesis provides a sustainable route to DNA production. However, the practical scalability of the underlying polymer...

#10 [14.5] Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials.

Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial tolerance. This matrix forms a dynamic macromolecular network of polysaccharides, proteins, extracellular DNA (e...

Methodology