Aptamer 学术简报 — 2026-07-30

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 168 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.9] Inception-level signal amplification: Cascaded DNAzyme-Cas9 nickase achieves sub-nanomolar kanamycin tracking.

BACKGROUND: Kanamycin's persistent contamination in agricultural products poses significant human health risks due to its nephrotoxicity and bioaccumulation via the food chain. Existing methods for on-site kanamycin monitoring lack sufficient sensitivity and portability, limiting their utility in field settings. The urgent need for rapid detecti...

#2 [16.9] The integration of peptoid and phosphorothioate aptamer into electrochemical biosensors for the robust antifouling detection of prostate-specific antigen in human serum.

Electrochemical biosensors for biomarker detection in complex biological media often suffer from performance degradation. Two main causes are non-specific adsorption of biomolecules and enzymolysis of immobilized biomolecules. Consequently, the development of robust antifouling electrochemical biosensors represents an imperative research task. W...

#3 [14.5] Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase‐Separation–Based Intelligent Drug Delivery

Functionalized coacervates, a type of nanomaterial inspired by biomolecular condensation, have emerged as an important research direction in biomedicine, particularly in cancer therapy. These membraneless structures formed by liquid-liquid phase separation (LLPS) self-assembly have high drug-loading capacity, favorable biocompatibility, and tuna...

#4 [14.2] A Wearable Extracorporeal Device for Imaging‐Guided Therapy of Sepsis Through Rapid Removal of Bacteria

ABSTRACT Sepsis is a severe infectious disease triggered by pathogenic bacteria invading the bloodstream, with mortality risk increasing by 7%–9% for each hour of delayed treatment. Real‐time pathogen monitoring and rapid intervention are crucial for the timely and effective management of sepsis. Here, we show that a wearable extracorporeal bloo...

#5 [13.5] EPGD co-delivery of doxorubicin and gemcitabine enhances activity in EpCAM-high tumour models with lower renal injury-associated readouts in a microfluidic co-culture platform.

Cytotoxic chemotherapy remains indispensable for many epithelial malignancies, yet gemcitabine (GEM) and doxorubicin (DOX) are constrained by a narrow therapeutic index and clinically significant toxicity. Here, we developed an epithelial cell adhesion molecule (EpCAM)-targeted DNA aptamer (EP)-based construct for co-delivery of GEM and DOX and ...

#6 [13.5] Detection of Point Mutation in Individual Living Circulating Malignant Cells by Targeting Molecular Beacon Delivery.

As a prevalent form of genetic alteration, single-base substitution serves as a critical determinant of targeted cancer therapeutic strategies and a driver of acquired drug resistance. Despite its clinical significance, detecting these mutations at the single-cell level remains challenging due to high costs, long analysis times, and difficulties...

#7 [13.2] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#8 [13.2] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#9 [13.0] An Electro-Fenton-Driven Self-Ratio Electrochemiluminescence Sensing Platform without a Coreactant for Sensitive and Accurate Monitoring of Antibiotics.

A ratiometric electrochemiluminescence (ECL) sensor with a self-calibration function can significantly enhance the detection accuracy of analytes. However, the requirement for two suitable ECL emitters and their corresponding coreactants often limits its practical applicability. In this study, luminol was employed as a single ECL emitter combine...

#10 [13.0] Steric-gated nanochannel biosensor for amplification-free electrochemical quantification of microbial DNA and RNA in aquatic environments

Methodology