Aptamer 学术简报 — 2026-07-15

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 253 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [16.5] Magnetically induced aggregation-assisted mesoporous polydopamine/single-atom nanozyme platform for dual-channel detection and two-stage synergistic eradication of pathogens.

Contamination with foodborne pathogenic bacteria poses a severe threat to public health, necessitating the integration of detection with source sterilization technologies. Herein, we developed an integrated nanoplatform by combining an aptamer-modified mesoporous polydopamine/palladium single-atom carbon dot composite probe (MPDA/Pd SA@DA-CDs/Ap...

#3 [15.9] A Fentanyl-Responsive Microneedle Patch for Harm Reduction.

The efficacy of current opioid overdose interventions is fundamentally limited by their reliance on bystander detection and administration, leaving unwitnessed overdoses, a predominant cause of fatalities, unaddressed. Herein, we developed an innovative fentanyl-responsive microneedle (MN) patch (iNal patch) engineered as an autonomous harm redu...

#4 [15.2] Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition

#5 [14.8] A Targeted Nanozyme for STING Activation Improves BiTEs Therapy Outcomes in Colorectal Cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with limited efficacy of conventional therapies due to immunosuppressive tumor microenvironments and high recurrence. While bispecific T-cell engagers (BiTEs) show promise by engaging T cells against tumors, their clinical translation is hindered by poor stabi...

#6 [14.5] Coordination‐Driven Metal‐Phenolic Network Complexes for Programmable Colorimetric Signal Transduction and Defined Nano‐Bio Interfaces

Self-assembled coordination networks provide opportunities to engineer functional nanostructures with programmable physicochemical properties, yet their optical responses and nano-bio interfacial interactions remain poorly understood. Herein, we employ a coordination-driven self-assembly approach to construct metal-phenolic network complexes (MP...

#7 [13.7] Plasma-SELEX for Acute Myocardial Infarction Biomarker Discovery and Diagnosis.

Early diagnosis of acute diseases is fundamentally constrained by the lack of chemically tractable methods for biomarker discovery directly from a complex plasma. Here, we report PSABD (plasma-SELEX-enriched aptamer-based biomarker discovery and diagnosis), a chemical platform that integrates carboxylate magnetic-bead-mediated plasma protein cap...

#8 [13.7] Colorimetric/Fluorescent/SERS Triple-Mode Synergistic Sensing for Highly Sensitive and Accurate Cardiac Troponin I Detection.

Cardiac troponin I (cTnI) is a cardiomyocyte-specific protein, and its serum level positively correlates with the degree of myocardial damage, making it a gold-standard biomarker for the clinical diagnosis of acute myocardial infarction (AMI). Nevertheless, conventional strategies for cTnI detection generally suffer from insufficient sensitivity...

#9 [13.6] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies.

Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins, and efficiently optimizing their binding affinities, remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental vali...

#10 [13.6] Therapeutic platforms for cancer management centered on blocking the PD-L1/PD-1 interaction through the use of aptamers: A review.

Blocking the PD-1/PD-L1 (Programmed Cell Death Protein-1/Programmed Cell Death Ligand-1) pathway represents a pivotal approach in cancer immunotherapy, effectively promoting sustained antitumor immune responses while alleviating immunosuppressive mechanisms. Advancing novel technologies to enhance the efficacy of PD-1/PD-L1 blockade remains a cr...

Methodology