Aptamer 学术简报 — 2026-06-24

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 168 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [26.0] A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3.

BACKGROUND: Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences in complex biological samples and ...

#2 [17.4] Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis.

Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dual-readout KIM-1 detection h...

#3 [14.9] Anti-CRISPR Protein Regulates CRISPR/Cas12a Fusogenic-Nanovesicle-Based Platform for Extracellular Vesicle-Encapsulated Non-Nucleic Acid Target In-Vesicle Detection.

The detection of non-nucleic acid targets encapsulated in extracellular vesicles (EVs) faces two major challenges: (1) difficulties in efficient isolation and the risk of content degradation, and (2) the low abundance of target molecules encapsulated in EVs always leads to failed signal transduction and inadequate output signal intensity. To ove...

#4 [14.7] Late-Stage Carboranylation of Nucleos(t)ides Enabled by Minisci and Pd-Catalyzed B-N Cross-Coupling Reactions: Toward the Synthesis of Carboranyl-Modified Oligonucleotides.

Carboranyl-modified nucleosides are promising boron-10 (10B) delivery agents for boron neutron capture therapy (BNCT), yet methods for directly forming B-C/B-N bonds at unprotected nucleosides are scarce. We report herein two operationally simple, orthogonal strategies for the late-stage installation of carboranyl units at heteroaromatic C(sp2) ...

#5 [14.5] Chirality-Induced Spin-Selective Transduction of Circularly Polarized Light for Polarization–Neurochemical Coupling

Circularly polarized light (CPL) provides a powerful optical degree of freedom for information encoding, yet most CPL-responsive systems rely on weak circular dichroism-based absorption and lack chemically amplified readout mechanisms. Here, we report a chirality-driven spin-photonic transduction platform in which CPL helicity is converted into ...

#6 [14.3] Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure-Enabled Lateral Flow Assay.

Early, rapid on-site detection of viral pathogens in livestock is critical to prevent disease spread, minimize economic losses, and safeguard food security. However, most current diagnostics are limited to centralized laboratories or require specialized equipment such as electrochemical readers, with a few hours to multi-day turnaround times tha...

#7 [14.0] Aptagel Plasmonic Fiber Optic Biosensor for In Vivo Continuous Drug Monitoring.

Continuous monitoring of drug dynamics directly in living tissue remains a major challenge, notably in the brain, where the blood-brain barrier creates distinct microenvironments. Here, we report an implantable fiber optic surface plasmon resonance (FO-SPR) biosensor coated with aptagel, a split-aptamer-crosslinked hydrogel, for continuous monit...

#8 [14.0] Combining G-Quadruplex and Non-Quadruplex Aptamers with Distinct Thermodynamic Driving Forces for Highly Selective Pb(2+) Detection.

Lead ions (Pb2+) are important contaminants and have also emerged as valuable cofactors in nucleic acid chemistry. Both G-quadruplex (G4)-forming sequences and in vitro selected aptamers have been extensively explored for Pb2+ binding and detection. Here, aptamer selection was conducted using a low Pb2+ concentration (10 μM) and an extended incu...

#9 [13.9] Selection of high-affinity optimer aptamers for A-type inclusion proteins and designing of optimer-enabled photonic crystal paper device for recognition of poxviruses.

We present an optimer-enabled photonic crystal paper device (OPCD) for rapid, multiplexed detection of orthopoxviruses, alongside a fundamental insight into aptamer structure-function relationships. By systematically truncating computationally designed 40-nucleotide DNA aptamers targeting A-type inclusion protein (A27L) proteins from cowpox, mon...

#10 [13.5] Target-Specific Recognition and Standardized Readout: A DNA Nanotransduction Strategy for Nanopore Exosome Sensing toward Clinical Applications.

Solid-state nanopores are powerful single-molecule sensing tools, but their reliance on direct translocation requires high analyte concentrations and complicates biochemical specificity. We propose a DNA nanotransduction strategy featuring target-specific molecular recognition and standardized electrical readout, converting complex vesicular inf...

Methodology