Aptamer 学术简报 — 2026-06-23

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 166 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [28.9] A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3.

BACKGROUND: Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences in complex biological samples and ...

#2 [18.1] Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis.

Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dual-readout KIM-1 detection h...

#3 [15.2] Anti-CRISPR Protein Regulates CRISPR/Cas12a Fusogenic-Nanovesicle-Based Platform for Extracellular Vesicle-Encapsulated Non-Nucleic Acid Target In-Vesicle Detection.

The detection of non-nucleic acid targets encapsulated in extracellular vesicles (EVs) faces two major challenges: (1) difficulties in efficient isolation and the risk of content degradation, and (2) the low abundance of target molecules encapsulated in EVs always leads to failed signal transduction and inadequate output signal intensity. To ove...

#4 [15.0] Late-Stage Carboranylation of Nucleos(t)ides Enabled by Minisci and Pd-Catalyzed B-N Cross-Coupling Reactions: Toward the Synthesis of Carboranyl-Modified Oligonucleotides.

Carboranyl-modified nucleosides are promising boron-10 (10B) delivery agents for boron neutron capture therapy (BNCT), yet methods for directly forming B-C/B-N bonds at unprotected nucleosides are scarce. We report herein two operationally simple, orthogonal strategies for the late-stage installation of carboranyl units at heteroaromatic C(sp2) ...

#5 [14.8] Chirality-Induced Spin-Selective Transduction of Circularly Polarized Light for Polarization–Neurochemical Coupling

Circularly polarized light (CPL) provides a powerful optical degree of freedom for information encoding, yet most CPL-responsive systems rely on weak circular dichroism-based absorption and lack chemically amplified readout mechanisms. Here, we report a chirality-driven spin-photonic transduction platform in which CPL helicity is converted into ...

#6 [13.8] Target-Specific Recognition and Standardized Readout: A DNA Nanotransduction Strategy for Nanopore Exosome Sensing toward Clinical Applications.

Solid-state nanopores are powerful single-molecule sensing tools, but their reliance on direct translocation requires high analyte concentrations and complicates biochemical specificity. We propose a DNA nanotransduction strategy featuring target-specific molecular recognition and standardized electrical readout, converting complex vesicular inf...

#7 [13.8] A Multifunctional Nucleic Acid Nanomedicine Coregulates Angiogenesis and Fibrosis to Treat Oral Submucous Fibrosis.

Oral submucous fibrosis (OSF) is a chronic progressive oral fibrotic disorder characterized by dysregulated immune inflammation, fibroblast activation, and vascular homeostasis disruption, yet synchronously regulating these axes remains challenging. We developed a multifunctional nucleic acid nanomedicine, Apt02-tFNAs-siTGF-β (A-T-S), in which t...

#8 [13.8] NHAPL enables homogeneous detection of RNA-associated glycan signals.

GlycoRNAs, newly identified RNA molecules bearing glycan modifications on cell membranes, are implicated in cell communication and immune regulation. However, current methodological limitations impede a thorough elucidation of their biological roles and clinical significance. Here, we developed Nucleotides Hybridization and Aptamer-based Proximi...

#9 [13.7] Multidimensional Pathogen Fingerprinting via DNA Scaffold-Confined Enzymatic Synthesis of Silicon Quantum Dots.

Accurate and highly sensitive detection of pathogenic bacteria is essential to public health. Conventional biosensors often rely on bulk signal amplification, which suffers from diffusion-limited kinetics and high background signals. Herein, we present a programmable, surface-confined biosensing strategy that constructs a target-responsive nucle...

#10 [13.5] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

Methodology