Aptamer 学术简报 — 2026-06-19

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 162 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.6] Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis.

Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dual-readout KIM-1 detection h...

#2 [18.4] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#3 [14.8] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

#4 [14.3] An Engineered Core-Satellite Magnetic Aptasensor with Built-In Calibration and Regeneration for Accurate Quantification of Oral Cancer Exosomes.

Exosomes carry diverse biologically active substances that can be transferred between cells, thereby influencing physiological and pathological states of the organism. Abnormal exosome levels are closely associated with cancer. Consequently, the precise detection of exosomes holds considerable importance for noninvasive cancer diagnosis and moni...

#5 [14.0] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#6 [14.0] Real-Time Monitoring of Trastuzumab Monoclonal Antibodies Using Electrochemical Aptamer-Based Sensors.

The real-time monitoring of trastuzumab (Tmab), a monoclonal antibody used for cancer treatment, is critical for personalized, response-guided dosing and improved biomanufacturing quality control. Currently, Tmab concentrations are quantified using immunoassays and mass spectrometry, but these platforms provide only discrete measurements and req...

#7 [14.0] Aptamer-functionalized 2D photonic crystal hydrogels for sensitive and selective Hg(2+) detection.

A two-dimensional photonic crystal hydrogel (2DPCH) sensor functionalized with aptamers has been developed for the highly sensitive detection of Hg2+ in water. The sensing mechanism relies on the specific formation of T- Hg2+-T hairpin structures between Hg2+ and the aptamers, inducing hydrogel contraction and altering the spacing between embedd...

#8 [14.0] Luminescent hydrogel-enabled electrochemiluminescent aptasensor and portable analyzer for on-site quantification of acetamiprid in vegetables.

Acetamiprid residues in vegetables threaten human health and food safety, necessitating rapid, sensitive detection. Electrochemiluminescence (ECL) is highly sensitive but suffers from matrix-induced quenching and high-voltage photomultiplier tubes (PMT). Here we co-load N-(4-aminobutyl)-N-ethylisoluminol (ABEI), MnO2 nanosheets (MnO2NSs), and go...

#9 [13.9] A combined ultrasound-enzymolysis-peptide aptamers strategy for reducing whey protein concentrate allergenicity in infant formula.

This study developed a combined ultrasound-enzymolysis-peptide aptamers method to reduce residual antigenicity of whey protein concentrate (WPC) in infant formula. The results indicated that 150 W ultrasonic treatment significantly altered the structure of WPC, increasing the β-sheet content by 14.55%, maximizing the exposure of total and surfac...

#10 [13.9] Spatiotemporal engineering to unlock one-pot CRISPR/Cas12a-based biosensor

Methodology