Aptamer 学术简报 — 2026-06-18

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 155 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [22.9] Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis.

Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dual-readout KIM-1 detection h...

#2 [19.0] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#3 [15.2] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

#4 [14.3] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#5 [14.3] Aptamer-functionalized 2D photonic crystal hydrogels for sensitive and selective Hg(2+) detection.

A two-dimensional photonic crystal hydrogel (2DPCH) sensor functionalized with aptamers has been developed for the highly sensitive detection of Hg2+ in water. The sensing mechanism relies on the specific formation of T- Hg2+-T hairpin structures between Hg2+ and the aptamers, inducing hydrogel contraction and altering the spacing between embedd...

#6 [14.3] Luminescent hydrogel-enabled electrochemiluminescent aptasensor and portable analyzer for on-site quantification of acetamiprid in vegetables.

Acetamiprid residues in vegetables threaten human health and food safety, necessitating rapid, sensitive detection. Electrochemiluminescence (ECL) is highly sensitive but suffers from matrix-induced quenching and high-voltage photomultiplier tubes (PMT). Here we co-load N-(4-aminobutyl)-N-ethylisoluminol (ABEI), MnO2 nanosheets (MnO2NSs), and go...

#7 [14.0] Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

Nucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, enabling precise and programmable functional modulation. However, low biostability remains a key druggability bottleneck of therapeutic aptamers. In vivo enzymatic lability constitutes a primary pharmacokinetic barrier, imp...

#8 [13.9] Redox- and Photo-Responsive Fe(3+/2+)-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

The synthesis of redox-active Fe3+-cross-linked carboxymethyl cellulose methacrylate cryogels (Fe3+-CMCMA), revealing switchable, transient, dissipative stiffness properties, is introduced. The switchable, transient functions are triggered by ascorbate-mediated reduction of the high-stiffness gel to the lower-stiffness Fe2+-CMCMA gel, and the co...

#9 [13.7] Reagent-Free Molecular Pendulum Biosensor with Antibody-Aptamer Dual Recognition for Protein Analysis.

The development of reagent-free biosensors that can continuously monitor proteins in complex biological fluids is still a critical unmet need. Molecular pendulum sensors have recently emerged as a promising reagent-free platform, enabling direct biomolecule detection without interference from surrounding matrices. However, conventional molecular...

#10 [13.5] Dual-Single-Atom Catalyst with Aptamer-Engineered Confined Reactive Milieu for Spatiotemporally Controlled Selective Conversion.

Spatiotemporal control of short-lived reactive intermediates remains a central challenge in heterogeneous catalysis, as non-selective diffusion fundamentally limits efficiency in complex media. Inspired by enzymatic compartmentalization, we report an aptamer-functionalized Au-Fe dual-single-atom catalyst (Apt-Au1-Fe1/NC) that mimics nature's pre...

Methodology