Aptamer 学术简报 — 2026-06-17

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 159 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [24.7] Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis.

Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dual-readout KIM-1 detection h...

#2 [19.7] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#3 [14.8] Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

Nucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, enabling precise and programmable functional modulation. However, low biostability remains a key druggability bottleneck of therapeutic aptamers. In vivo enzymatic lability constitutes a primary pharmacokinetic barrier, imp...

#4 [14.7] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#5 [14.6] Aptamer-functionalized 2D photonic crystal hydrogels for sensitive and selective Hg(2+) detection.

A two-dimensional photonic crystal hydrogel (2DPCH) sensor functionalized with aptamers has been developed for the highly sensitive detection of Hg2+ in water. The sensing mechanism relies on the specific formation of T- Hg2+-T hairpin structures between Hg2+ and the aptamers, inducing hydrogel contraction and altering the spacing between embedd...

#6 [14.6] Luminescent hydrogel-enabled electrochemiluminescent aptasensor and portable analyzer for on-site quantification of acetamiprid in vegetables.

Acetamiprid residues in vegetables threaten human health and food safety, necessitating rapid, sensitive detection. Electrochemiluminescence (ECL) is highly sensitive but suffers from matrix-induced quenching and high-voltage photomultiplier tubes (PMT). Here we co-load N-(4-aminobutyl)-N-ethylisoluminol (ABEI), MnO2 nanosheets (MnO2NSs), and go...

#7 [14.3] Redox- and Photo-Responsive Fe(3+/2+)-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

The synthesis of redox-active Fe3+-cross-linked carboxymethyl cellulose methacrylate cryogels (Fe3+-CMCMA), revealing switchable, transient, dissipative stiffness properties, is introduced. The switchable, transient functions are triggered by ascorbate-mediated reduction of the high-stiffness gel to the lower-stiffness Fe2+-CMCMA gel, and the co...

#8 [14.0] Reagent-Free Molecular Pendulum Biosensor with Antibody-Aptamer Dual Recognition for Protein Analysis.

The development of reagent-free biosensors that can continuously monitor proteins in complex biological fluids is still a critical unmet need. Molecular pendulum sensors have recently emerged as a promising reagent-free platform, enabling direct biomolecule detection without interference from surrounding matrices. However, conventional molecular...

#9 [13.9] Dual-Single-Atom Catalyst with Aptamer-Engineered Confined Reactive Milieu for Spatiotemporally Controlled Selective Conversion.

Spatiotemporal control of short-lived reactive intermediates remains a central challenge in heterogeneous catalysis, as non-selective diffusion fundamentally limits efficiency in complex media. Inspired by enzymatic compartmentalization, we report an aptamer-functionalized Au-Fe dual-single-atom catalyst (Apt-Au1-Fe1/NC) that mimics nature's pre...

#10 [13.8] A supersandwich fluorescent aptasensor leveraging the synergy of mini-nanotetrahedron, high-affinity split aptamer and rolling circle amplification for kanamycin analysis in milk.

Sensitive detection of kanamycin (KAN) is vital for ensuring food safety. In this study, a novel fluorescent aptasensor for KAN detection was developed by synergizing high-affinity split aptamers, a miniaturized DNA nanotetrahedron (mini-NTH) scaffold, and rolling circle amplification (RCA). Contrasting conventional views, the split aptamers exh...

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