Aptamer 学术简报 — 2026-06-14

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 228 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [22.2] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#2 [18.3] A dual-mode electrochemiluminescence/SERS biosensor for B-type natriuretic peptide based on a T7-CRISPR/Cas13a cascade and a CsPbBr(3)@PDA@Au perovskite interface.

B-type natriuretic peptide (BNP) is an important biomarker for cardiovascular diseases, motivating sensitive and robust quantification in complex matrices. Here we report a single-electrode, anti-correlated dual-mode electrochemiluminescence/surface-enhanced Raman scattering (ECL/SERS) biosensor that couples split-aptamer recognition with a solu...

#3 [18.1] Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.

Nucleic acid aptamers are synthetic, single-stranded oligonucleotides that bind targets with high affinity and specificity, enabling precise and programmable functional modulation. However, low biostability remains a key druggability bottleneck of therapeutic aptamers. In vivo enzymatic lability constitutes a primary pharmacokinetic barrier, imp...

#4 [14.9] Dual-Single-Atom Catalyst with Aptamer-Engineered Confined Reactive Milieu for Spatiotemporally Controlled Selective Conversion.

Spatiotemporal control of short-lived reactive intermediates remains a central challenge in heterogeneous catalysis, as non-selective diffusion fundamentally limits efficiency in complex media. Inspired by enzymatic compartmentalization, we report an aptamer-functionalized Au-Fe dual-single-atom catalyst (Apt-Au1-Fe1/NC) that mimics nature's pre...

#5 [14.7] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#6 [14.7] Recognition of non-standard base pairs by triplex-forming oligonucleotides containing an expanded genetic alphabet

Abstract The sequence-specific recognition of double-stranded DNA by biocompatible molecules is fundamental to molecular medicine and synthetic biology. Triplex-forming oligonucleotides (TFOs) enable programmable major groove recognition via Hoogsteen base pairing; however, the limited repertoire of natural nucleobases imposes strict constraints...

#7 [14.0] Advancing point-of-care diagnostics: Engineering and enhancing sensitivity and specificity in nanoparticle-based lateral flow assays for rapid disease detection.

Lateral flow assay (LFA) is the most widely used point-of-care (PoC) diagnostic tools due to their simplicity, rapid turnaround, portability, and low cost. Despite their extensive adoption in clinical diagnostics, food safety, and environmental monitoring, conventional LFA remain limited by inadequate sensitivity, poor quantification, and restri...

#8 [14.0] Switch-type photoelectrochemical aptasensor for microplastics and nanoplastics detection based on two-dimensional organic-inorganic heterojunction.

Microplastics and nanoplastics (MNPs) as emerging pollutants present substantial risks to both the environment and human health. Developing highly sensitive methods to rapidly identify and detect low concentrations of MNPs in complex systems remains a considerable challenge. Here, an "off-on" switch-type photoelectrochemical (PEC) aptasensor was...

#9 [14.0] Organic electrochemical transistors (OECT) based biosensors for the detection of small molecule metabolites.

Recently, organic electrochemical transistors (OECTs) have emerged as robust platforms for chemical and biological sensing, due to their intrinsic signal amplification, biocompatibility, and low-voltage functionality. OECTs have exhibited tremendous promise for detecting small molecule metabolites (SMMs), which are crucial as biomarkers in medic...

#10 [13.9] Multifunctional DNA Nanoplatform Based on CuInS/ZnS QDs and Rolling Circle Amplification for Synergistic PTT/CDT/CT of Multidrug Resistant Cancer Cells.

Synergistic therapy holds significant potential in cancer diagnosis and treatment, yet faces substantial challenges such as nonspecific drug release and tumor multidrug resistance (MDR). Herein, we report a self-assembled DNA nanoplatform (ZCIS QDs@RD) based on CuInS/ZnS QDs (ZCIS QDs) and rolling circle amplification (RCA) for synergistic photo...

Methodology