Aptamer 学术简报 — 2026-06-04

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 221 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [26.9] A dual-mode electrochemiluminescence/SERS biosensor for B-type natriuretic peptide based on a T7-CRISPR/Cas13a cascade and a CsPbBr(3)@PDA@Au perovskite interface.

B-type natriuretic peptide (BNP) is an important biomarker for cardiovascular diseases, motivating sensitive and robust quantification in complex matrices. Here we report a single-electrode, anti-correlated dual-mode electrochemiluminescence/surface-enhanced Raman scattering (ECL/SERS) biosensor that couples split-aptamer recognition with a solu...

#2 [22.1] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#3 [22.1] Engineered dual-fluorescence functional nucleic acid-based CRISPR/Cas12a biosensor for label-free ratiometric detection of site-specific DNA methylation.

The CRISPR/Cas12a system holds significant promise for biomedical applications. Nevertheless, the commonly used reporter, fluorophore-quencher-labeled substrates, is hindered by labor-intensive synthesis procedures and high costs, while also relying on a single-photon method and being vulnerable to environmental interference. Herein, a label-fre...

#4 [21.9] Advancing point-of-care diagnostics: Engineering and enhancing sensitivity and specificity in nanoparticle-based lateral flow assays for rapid disease detection.

Lateral flow assay (LFA) is the most widely used point-of-care (PoC) diagnostic tools due to their simplicity, rapid turnaround, portability, and low cost. Despite their extensive adoption in clinical diagnostics, food safety, and environmental monitoring, conventional LFA remain limited by inadequate sensitivity, poor quantification, and restri...

#5 [21.9] Switch-type photoelectrochemical aptasensor for microplastics and nanoplastics detection based on two-dimensional organic-inorganic heterojunction.

Microplastics and nanoplastics (MNPs) as emerging pollutants present substantial risks to both the environment and human health. Developing highly sensitive methods to rapidly identify and detect low concentrations of MNPs in complex systems remains a considerable challenge. Here, an "off-on" switch-type photoelectrochemical (PEC) aptasensor was...

#6 [20.6] An electrochemical biosensing platform based on α‑iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.

The detection of biologically active proteins in complex biological matrices such as serum remains challenging. To enhance the sensitivity and accuracy of detecting the hepatocellular carcinoma biomarker stress-induced phosphoprotein 1 (STIP1), we proposed a label-free "Turn-off" electrochemical aptamer-based biosensing platform without requirin...

#7 [20.6] Gold nanoparticle-modified graphene oxide electrochemical aptasensor for ultrasensitive detection of interferon gamma in kidney transplants.

The early and accurate detection of interferon gamma (IFN-γ), a key cytokine in acute cellular rejection following kidney transplantation, is essential for effective immunosuppressive management. Current methods often lack the sensitivity, speed, or simplicity for routine clinical immunomonitoring. Here, we developed a novel electrochemical apta...

#8 [18.1] Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.

BACKGROUND: Joint use of multiple molecular layers can be useful to prioritize targets for mechanistic studies. Application of this approach to coronary disease in large populations is an emerging field. METHODS: We used reported circulating proteomic data (Somascan aptamer-based) from ≈3000 individuals in the CARDIA study (Coronary Artery Risk ...

#9 [15.2] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#10 [14.5] Modular Vaccine Robots for Spatiotemporal Programming of the CD4(+) T Cell-Myeloid Cell Axis.

Here, we developed a magnetically driven modular Janus vaccine robot (MVR) with orthogonally functional domains to achieve spatiotemporal coordination of CD4+ T cell-myeloid cell-mediated tumor killing. The oleic acid-modified CoFe2O4 (OA@CF) and carboxyl-modified T cell-targeting aptamers are selectively assembled onto the hydrophobic and hydro...

Methodology