Aptamer 学术简报 — 2026-06-02

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 236 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [31.6] A dual-mode electrochemiluminescence/SERS biosensor for B-type natriuretic peptide based on a T7-CRISPR/Cas13a cascade and a CsPbBr(3)@PDA@Au perovskite interface.

B-type natriuretic peptide (BNP) is an important biomarker for cardiovascular diseases, motivating sensitive and robust quantification in complex matrices. Here we report a single-electrode, anti-correlated dual-mode electrochemiluminescence/surface-enhanced Raman scattering (ECL/SERS) biosensor that couples split-aptamer recognition with a solu...

#2 [26.8] Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.

Cardiovascular diseases (CVDs) are globally prevalent pathologies driven by dysregulated signaling networks. Circular RNAs (circRNAs), a class of covalently closed non-coding RNAs produced by back-splicingmechanism, in which a downstream 5' splice site joins an upstream 3' splice site, have emerged as critical regulators of CVD pathogenesis. Thi...

#3 [26.8] Engineered dual-fluorescence functional nucleic acid-based CRISPR/Cas12a biosensor for label-free ratiometric detection of site-specific DNA methylation.

The CRISPR/Cas12a system holds significant promise for biomedical applications. Nevertheless, the commonly used reporter, fluorophore-quencher-labeled substrates, is hindered by labor-intensive synthesis procedures and high costs, while also relying on a single-photon method and being vulnerable to environmental interference. Herein, a label-fre...

#4 [26.6] Advancing point-of-care diagnostics: Engineering and enhancing sensitivity and specificity in nanoparticle-based lateral flow assays for rapid disease detection.

Lateral flow assay (LFA) is the most widely used point-of-care (PoC) diagnostic tools due to their simplicity, rapid turnaround, portability, and low cost. Despite their extensive adoption in clinical diagnostics, food safety, and environmental monitoring, conventional LFA remain limited by inadequate sensitivity, poor quantification, and restri...

#5 [26.6] Switch-type photoelectrochemical aptasensor for microplastics and nanoplastics detection based on two-dimensional organic-inorganic heterojunction.

Microplastics and nanoplastics (MNPs) as emerging pollutants present substantial risks to both the environment and human health. Developing highly sensitive methods to rapidly identify and detect low concentrations of MNPs in complex systems remains a considerable challenge. Here, an "off-on" switch-type photoelectrochemical (PEC) aptasensor was...

#6 [25.3] An electrochemical biosensing platform based on α‑iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.

The detection of biologically active proteins in complex biological matrices such as serum remains challenging. To enhance the sensitivity and accuracy of detecting the hepatocellular carcinoma biomarker stress-induced phosphoprotein 1 (STIP1), we proposed a label-free "Turn-off" electrochemical aptamer-based biosensing platform without requirin...

#7 [25.3] Gold nanoparticle-modified graphene oxide electrochemical aptasensor for ultrasensitive detection of interferon gamma in kidney transplants.

The early and accurate detection of interferon gamma (IFN-γ), a key cytokine in acute cellular rejection following kidney transplantation, is essential for effective immunosuppressive management. Current methods often lack the sensitivity, speed, or simplicity for routine clinical immunomonitoring. Here, we developed a novel electrochemical apta...

#8 [15.0] Hydrovoltaic-photoelectric coupling effect boosted self-powered aptasensor for on-site and ultrasensitive monitoring of enrofloxacin in aquaculture products based on CdS/ZIF-67 heterojunctions.

On-site monitoring of antibiotic residues in aquaculture products is of great significance for providing instant content information to protect food safety and human health. In this work, a novel hydrovoltaic self-powered electrochemical sensor was fabricated for real-time sensitive detection of enrofloxacin (ENR) by integration of photoelectric...

#9 [14.3] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#10 [13.9] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

Methodology