Aptamer 学术简报 — 2026-05-31

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 212 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.2] Hydrovoltaic-photoelectric coupling effect boosted self-powered aptasensor for on-site and ultrasensitive monitoring of enrofloxacin in aquaculture products based on CdS/ZIF-67 heterojunctions.

On-site monitoring of antibiotic residues in aquaculture products is of great significance for providing instant content information to protect food safety and human health. In this work, a novel hydrovoltaic self-powered electrochemical sensor was fabricated for real-time sensitive detection of enrofloxacin (ENR) by integration of photoelectric...

#2 [14.3] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#3 [14.1] A one-step electrochemical strategy for rapid exosome detection using Cu(2+)-coordinated DNA nanoparticles.

Stimulus-responsive nucleic acid nanomaterials are attractive for label-free electrochemical biosensing because their programmable structures enable target-triggered signal generation in homogeneous systems. Herein, we report a one-step electrochemical strategy for rapid and highly sensitive detection of ovarian cancer (OC)-derived exosomes base...

#4 [14.1] Heteroaptamer recognition mediated strand displacement amplification for efficient electrochemical analysis of beta-2-microglobulin in breast milk.

The human milk protein beta-2-microglobulin (B2M) plays a vital role as a diagnostic biomarker for infants, with conventional detection methods frequently relying on intricate instruments that have constraints in sensitivity and selectivity. Here, an innovative heteroaptamer recognition-mediated strand displacement amplification for electrochemi...

#5 [14.1] Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries.

Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable ...

#6 [14.0] Discriminating Post-Transplant Rejection from Infection by Detecting TCR-CD3 Oligomerization on Extracellular Vesicles Using a Ratiometric Caliper Probe.

Post-transplant rejection and infection remain significant obstacles to long-term patient survival. However, there is currently no standardized assay to simultaneously assess an individual patient's risk for both complications. Here, we demonstrate that T cell receptor (TCR)-CD3 oligomers on extracellular vesicles (EVs) represent a promising bio...

#7 [14.0] An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity.

Accurate quantification of 8-oxoguanine DNA glycosylase-1 (OGG1) activity in the cell nucleus is crucial for evaluating the DNA oxidative damage marker 8-oxoguanine (8-oxoG). However, due to the difficulty in nuclear localization and the predicament of strong signal output, subcellular imaging has not yet been achieved. Herein, we report a nucle...

#8 [13.7] Photothermal Recycling Biosensing for Continuous, Sensitive Molecular Quantification

Continuous biochemical sensing provides valuable insights into an individual’s physiological state and the mechanisms underlying pathophysiological changes. However, most existing bioanalytical methods are not compatible with continuous biochemical sensing. A major technical challenge lies in achieving rapid measurement readouts while maintainin...

#9 [13.3] DNA Tetrahedron-Mediated Sensing Platform on a Single Gold Nanowire: Special Signal Amplification, Self-Referencing Capability, and Cross-Validated Exosome Detection for Liver Cancer Liquid Biopsy.

Exosomes have emerged as promising biomarkers for noninvasive cancer diagnosis, while highly sensitive, reliable, and convenient assays remain challenging, particularly with conventional single-signal approaches. Herein, we report an exosome-tailored dual-mode self-referencing biosensing platform on a single gold nanowire (AuNW) substrate for th...

#10 [13.3] Development of a Core−Shell-Encapsulated Biosensor for On-Site Detection of Trace Chlorpyrifos

Chlorpyrifos, a broad-spectrum organophosphorus pesticide, accumulates persistently in the environment and food chain, posing significant risks to ecosystems and human health. Whole-cell biosensors offer a promising alternative for on-site pesticide detection. However, their practical application is hindered by insufficient sensitivity for trace...

Methodology