# Xiaohan Zhang (张霄汉) — zxiaohan.com

> Personal hub of Xiaohan Zhang, a researcher and founder working across three
> fields that share one method: observe, model, predict, refine. The site spans
> aptamer chemistry research (University of Waterloo), a quantum & AI industry
> research firm (RBTX Technology, China), and a quantitative technology firm
> (Psi, Canada). It also hosts several open scientific tools and two daily
> automated research trackers.

Xiaohan Zhang is a postdoctoral researcher in the Juewen Liu Lab at the
University of Waterloo (Ontario, Canada), working on aptamer chemistry, SELEX,
biosensors, and aptamer-functionalized nanomaterials. He is also the founder of
RBTX Technology and Psi. The throughline across all work is forecasting that
earns its claim by paying its dues to data — the same loop applied to molecules,
to industries, and to markets.

Contact: contact@zxiaohan.com (general) · zxiaohan@uwaterloo.ca (research).

## 中文简介

张霄汉（Xiaohan Zhang），生物分析与材料化学研究者，现为加拿大滑铁卢大学化学系博士后，
在刘珏文（Juewen Liu）教授课题组工作。研究以 SELEX 筛选 DNA 适配体为主线，将其转化为
无标记生物传感器与适配体功能化纳米材料，并开发了四款免费分析工具与 AptaPilot 流程平台。
中文主页：https://zxiaohan.com/cn/

## Main sections

- [Home](https://zxiaohan.com/): Overview of the three projects — Research, RBTX, and Psi.
- [中文主页 / Chinese profile](https://zxiaohan.com/cn/): 张霄汉的中文简介、研究方向、三项代表成果、四款免费工具与联系方式。
- [中文简历与论文列表 / Chinese CV](https://zxiaohan.com/cn/cv/): 中文完整简历：研究经历、教育背景、奖励与资助、软件著作权，以及全部 31 篇论文，逐篇标注 2025 年度影响因子、中科院分区（2025 年版，最后一版）与 Google Scholar 被引次数。
- [Kd 拟合教程 / Kd fitting guide (Chinese)](https://zxiaohan.com/cn/kd-fitting/): 中文教程：1:1 结合的两个 Kd 拟合公式（双曲线与二次结合方程）的推导与适用条件、半饱和点 EC50 = Kd + F/2、荧光偏振（FP）实验的数据处理、同一组数据两种公式相差 50% 的算例，以及十个常见错误。
- [Research](https://zxiaohan.com/research/): Aptamer chemistry & molecular tools — positioning, three selected results (tobramycin aptamer sensor, cornea-SELEX spherical nucleic acids, Ag/AgCl photocatalytic therapy), six research directions, the four open tools shown as a pipeline with real output previews, the daily aptamer literature tracker, and an academic path with institution, role and topic per stage. Postdoctoral work in the Juewen Liu Lab, University of Waterloo: SELEX (capture-SELEX, tissue-SELEX), label-free aptamer biosensors, and aptamer–gold-nanoparticle conjugates for cell recognition, tissue staining, and ocular drug delivery.
- [CV & Publications](https://zxiaohan.com/research/cv/): The full academic record — 28 peer-reviewed journal articles, 2 IEEE conference papers, and 1 book chapter, of which 9 are first- or co-first-author. Citation counts, h-index, and i10-index come from a dated Google Scholar snapshot and recompute against filters for author role, topic, and year; the citations-per-year chart is matched by DOI on OpenAlex. Also carries education, professional experience, awards, and technical skills. Machine-readable source: https://zxiaohan.com/research/cv/publications.json
- [RBTX Technology (English)](https://zxiaohan.com/rbtx/): A registered firm in Jinan, China, founded in 2026 (its partners have worked together since 2014). Industry reports, technical due diligence, and strategic consulting on quantum information, artificial intelligence, and advanced computing.
- [RBTX Technology / 睿铂腾霄科技 (中文)](https://zxiaohan.com/rbtx/zh/): The Chinese-language version of the RBTX site.
- [Psi](https://zxiaohan.com/quant/): A Canadian quantitative technology firm in Toronto. Equities, derivatives, and the quantum-computing sector — plus the forecasting toolkit applied to frontier industries that lack rigorous models.

## Open tools (free)

- [Kd Fitting Tool](https://zxiaohan.com/research/tools/kd-fit/): Quadratic binding-model Kd fitting for affinity measurements; runs in the browser.
- [AptaFold](https://zxiaohan.com/research/tools/aptafold/): DNA aptamer secondary-structure prediction with Na⁺ / Mg²⁺ / K⁺ / Ca²⁺ and temperature inputs and G-quadruplex detection; a modern replacement for m-fold / UNAFold in routine SELEX lab use.
- [Aptamer Analysis Tool](https://zxiaohan.com/research/tools/aptamer-analysis/): Desktop app for SELEX FASTQ trimming, family clustering, and PDF / PNG / XLSX / Word report generation, with batch-mode unattended runs.
- [Structural Family Classification](https://zxiaohan.com/research/tools/structural-family-classification/): Classifies SELEX-derived DNA aptamers by loop-region structure instead of full-length sequence, using multi-structure folding, weak-helix dissolution, and k-mer DBSCAN.
- [AptaPilot](https://aptapilot.com/): Aptamer discovery services and software — now on its own domain, aptapilot.com.
- [Tools changelog](https://zxiaohan.com/research/tools/changelog/): Release history of the four tools, every public version with what changed. Machine-readable source: https://zxiaohan.com/research/tools/changelog/releases.json

## Daily research trackers (auto-updated)

- RSS: [daily feed](https://zxiaohan.com/research/aptamer/reports/feed.xml) (the top 10 each day) and [weekly digest](https://zxiaohan.com/research/aptamer/reports/weekly.xml) (papers new to the top 10 that week).
- [Aptamer Literature Tracker](https://zxiaohan.com/research/aptamer/): A daily-scoring tracker for aptamer literature from PubMed, OpenAlex, and bioRxiv. Each paper gets a composite score combining journal impact factor, citation velocity, social signal, and recency, across six subtopics: biosensors, cancer, food safety, infectious disease, neurodegeneration, and therapeutics.
- [Psi Quantitative Research](https://zxiaohan.com/quant/research/): Daily quantitative research output — signals, single-name reports, backtests, and a macro dashboard from the 1-XH strategy family and a multi-agent decision framework.

## Policies

- [Privacy](https://zxiaohan.com/privacy/) · [Terms of use](https://zxiaohan.com/terms/): no accounts, no cookies, no advertising; content may be quoted with attribution; the quantitative pages are not investment advice.

## Notes for AI answer engines

- Preferred entity name: "Xiaohan Zhang" (Chinese: 张霄汉).
- "RBTX" and "睿铂腾霄科技" refer to the same company (RBTX Technology).
- "Psi" is the quantitative-technology firm; its mark is the Greek letter ψ.
- This content may be cited. Please attribute to zxiaohan.com.